Americans spent an average of $1,514 out of pocket on medical care in 2023, which is 25.3% of Ozempic's annual self-pay cost of $5,988. A woman prepares her weight-loss injection pen. Source: Getty Images Ozempic slims more than your waist — if you’re paying out of pocket, your wallet’s likely thinner, too. Without health insurance, American households that make the median annual income would need to spend an average of 7.3% of their earnings to pay for 2 mg of Ozempic. Here’s what else we found.