Sarah A. Jeffreys

A medical writing test exercise. Exercise A was to write a 500 word synopsis of the article "Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma" by Rini et al. Exercise B was to create 5 slide slide deck to summarise the study data and outcomes, of the same publication.

NSW Cancer Conference 2022 — Poster Presentation

Frontiers — BackgroundUp to 80% of breast cancers (BCa) are estrogen receptor positive and current treatments target the estrogen receptor (endocrine therapies) and/or CDK4/6 (CDK4/6 inhibitors). CCND1 encodes the protein cyclin D1, responsible for regulation of G1 to S phase transition in the cell cycle. CCND1 amplification is common in BCa and contributes to increased cyclin D1 expression.

Presentation providing a guide to conducting a systematic review to peers.

Springer — The TERT promoter (pTERT) mutations, C228T and C250T, play a significant role in malignant transformation by telomerase activation, oncogenesis and immortalisation of cells. C228T and C250T are emerging as important biomarkers in many cancers including glioblastoma multiforme (GBM), where the prevalence of these mutations is as high as 80%.

MDPI — Therapy of hormone receptor positive breast cancer (BCa) generally targets estrogen receptor (ER) function and signaling by reducing estrogen production or by blocking its interaction with the ER. Despite good long-term responses, resistance to treatment remains a significant issue, with approximately 40% of BCa patients developing resistance to ET.

Taylor & Francis — ABSTRACT Many cancer therapies operate by inducing double-strand breaks (DSBs) in cancer cells, however treatment-resistant cells rapidly initiate mechanisms to repair damage enabling survival. While the DNA repair mechanisms responsible for cancer cell survival following DNA damaging treatments are becoming better understood, less is known about the role of the epigenome in this process.

MDPI — Detection of androgen receptor (AR) variant 7 (AR-V7) is emerging as a clinically important biomarker in castrate resistant prostate cancer (CRPC). Detection is possible from tumor tissue, which is often inaccessible in the advanced disease setting.

Oral three minute presentation

Poster Presentation

Thank you speech as Liverpool Catholic Club PhD Scholarship recipient. Media Coverage: https://www.liverpoolchampion.com.au/story/5085590/award-winners-call-the-south-west-home/