David Adler
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Articles by David Adler
Elly's Statcast-record 102 mph throw puts kibosh on inside-the-parker
Fastest tracked assists by infielders, Statcast era (since 2015) 1. Elly De La Cruz: 102.0 mph, 9/9/2026 2-T. Elly De La Cruz: 99.8 mph, 8/8/2026 Watch > 2-T. Elly De La Cruz: 99.8 mph, 7/20/2023 Watch > 4. Elly De La Cruz: 99.7 mph, 8/27/2023 Watch > 5.
Trump’s Beijing blind spots: The two glaring holes in his war on high drug prices
President Donald Trump’s drug pricing policy has two China blind spots. The first is that Washington is pressing other developed economies to pay what it calls their fair share for pharmaceutical innovation, while China remains largely outside that burden-sharing effort, even as Chinese drug developers increasingly benefit from the high-priced American market through licensing and direct commercialization.
When Should R&D Organize Around The Therapy, Not Just The Drug?
By David Adler, M.D./Ph.D., MBA Co-development is an established concept. The practical question is how early its logic should shape candidate selection, development planning, and portfolio governance. Combination therapy is routine in oncology, and investigational co-development is not a new concept. Regulatory frameworks have long addressed circumstances in which two or more investigational therapies may appropriately be developed together.
Trump wants to cut NIH. What future medicines will your family lose?
The treatment your spouse, parent, or child may need 10 or 15 years from now might not exist today. Whether it eventually does could depend on biomedical research being funded now. That is what is ultimately at stake in President Donald Trump’s fiscal 2027 proposal for the National Institutes of Health. The FTC didn’t just save you money on prescription drugs.
Krav Maga: The Move We Did Not Plan For
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. Krav Maga is built for a simple reality: the person in front of you will not follow your plan.
The next Abraham Accords should formalize what has already been built
(Sept. 6, 2026 / JNS) The next Abraham Accords agreement should not just be the beginning of a partnership. By the time leaders are ready to normalize relations, institutions that can sustain that relationship should already exist. Israel’s own history offers an instructive analogy. Long before independence in May 1948, the Zionist Yishuv had built elected representative bodies, the Jewish Agency, health systems, universities, economic organizations and a viable defense structure.
09.06.26 -- Stopping A Drug Development Program Sometimes Creates More Value Than Continuing
Guest Column | Good R&D leadership is knowing when to keep investing in a development program, when to change course, and when to return to base, writes David Adler, M.D./Ph.D., MBA. Guest Column | Precision oncology only works when biomarker testing helps identify the right patients at scale before launch, explains Boehringer Ingelheim’s Vicky Brown.
A chemo shortage is headed for America. India just showed us why
This summer, cancer patients in India discovered that a chemotherapy shortage can begin far from a pharmaceutical factory, with a disruption in the supply of a metal. Cisplatin and carboplatin are decades-old generic drugs that remain a backbone of chemotherapy for many cancers. Both depend on platinum. When platinum prices more than doubled, Indian manufacturers struggled to obtain raw materials and absorb the higher costs.
A chemo shortage is headed for America. India just showed us why
15-year-old Tamil Nadu boy invented technology that would extend life of banana leaves from 3 days to 3 years for just 70 paise. His innovation saves 7 billion trees annually At 15, one boy wonder from Tamil Nadu came up with a magnificent technique that would make utensils from banana leaves last longer. According to a …
Efforts to Rehabilitate Nixon Threaten Constitutional Democracy
The ongoing efforts to rehabilitate Richard Nixon by the MAGA Right and various commentators, as well as Vice President JD Vance, represents a brazen attempt to whitewash the stain on the American escutcheon inflicted by the Watergate President, for the purpose of “normalizing” his politics, his sweeping acts of usurpation and abuse of power, to furnish President Trump with a historical precedent to absolve him of his Nixonian assault on our constitutional system.
Israel’s Brain-Drain Debate Is Asking the Wrong Question
Israel has good reason to worry about brain drain. Highly educated and highly skilled Israelis have opportunities to build their careers abroad, and for a small country whose economic strength depends heavily on knowledge, innovation and human capital, that matters. But the debate often focuses on the wrong measure. The most important question is not simply how many talented people leave Israel.
When the Iron Dome Chooses Not to Engage
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. The Iron Dome is an air-defense system designed to intercept incoming rockets. But an equally important part of the system is knowing when not to engage.
Three Cy Young contenders pitch tonight. All of them bring unique heat
Misiorowski, Schlittler and Yamamoto have three of the best fastballs in the Majors. They're all top five in terms of runs prevented. Most valuable 4-seam fastballs in 2026 1-T. Misiorowski: +25 runs prevented 1-T. Parker Messick: +25 runs prevented 3. Schlittler: +18 runs prevented 4. Yamamoto: +16 runs prevented We think that's interesting, because their heaters are also pretty different from one another. Tune in to watch them tonight, and you'll see.
Trump’s “America First” Drug-Development Policy Has Three Different Meanings
“America First” in drug development is not one objective. It can mean putting the American economy first, putting American patients first, or putting American strategic power first. Those goals often reinforce one another but are not interchangeable. When they conflict, “America First” does not tell policymakers which interest should prevail. That distinction matters because the administration is turning the slogan into policy.
When the Iron Dome Chooses Not to Engage
When the Iron Dome Chooses Not to Engage - David Adler
Commentary: Blanche’s expansion of executive privilege builds moat around White House
Amid headlines of failing health conditions — inadequate food and water — on the U.S.S. Lincoln, President Trump’s continued circumvention of Congress and the law while he erects monuments to himself, and his announcement that he will sell early access to his Truth Social Posts for $100,000 per month, which is a likely means of knowing how the president will manipulate the markets, comes the news of the Trump Administration’s latest maneuver to further undermine the rule of law and evade...
Taftefet (טפטפת): Where Should Israel’s Next Drop Go?
In 1959, Israeli water engineer Simcha Blass and his son Yeshayahu developed a basic drip-irrigation system they called Taftefet (טפטפת), Hebrew for “dripper.” Its purpose was elegantly simple. It released small amounts of water slowly and precisely, close to where a plant could actually use it. That breakthrough helped transform global agriculture. What made drip irrigation innovative was not simply that it used less water. It changed how water was delivered.
Taftefet (טפטפת): Where Should Israel’s Next Drop Go?
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post.
Israeli AI companies in biopharma R&D are not leaving Israel
(Aug. 29, 2026 / JNS) Israel is justified in its concerns over whether scientific, technological and economic value created by artificial intelligence companies in biopharma research and development will remain in the country as those companies develop and grow. Many such companies start with employees concentrated in Israel. Later, a share of their workforce and senior leadership may be based in the United States. As this trend gains momentum, it eventually means that the company leaves Israel.
Unit 8200: What Comes After the Signal?
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. Unit 8200 is Israel’s signals intelligence unit.
Unit 8200: What Comes After the Signal?
Unit 8200 is Israel’s signals intelligence unit. At its core, its job is to collect information, identify what matters, reduce uncertainty, and support better decisions about what to do next. Sometimes there is already a specific question. Information is gathered to reduce uncertainty and help de-risk a decision. Other times, the search is broader. Signals are collected, patterns emerge, and something unexpected may suddenly become important. And sometimes one signal is simply not enough.
Henderson is the Brewers' new high-spin changeup artist
This story was excerpted from Adam McCalvy's Brewers Beat newsletter, with MLB.com's David Adler filling in for this edition. To read the full newsletter, click here. And subscribe to get it regularly in your inbox. Changeups, as a general rule, are low-spin pitches. That's what makes them tumble. But if you watch the Brewers, that's just not what you see. Milwaukee has an unusual history of throwing high-spin changeups.
When Should R&D Turn Back?
By David Adler, M.D./Ph.D., MBA Why passing a development milestone does not necessarily justify the next investment Pharmaceutical R&D organizations are built to advance programs. But as a program moves from discovery into clinical development, one question can become surprisingly difficult to ask: “Given what we know today, would we still make the next investment?” A program may have reached an important milestone.
Blanche’s expansion of executive privilege builds a moat around the White House | David Adler
Amid headlines of failing health conditions — inadequate food and water — on the U.S.S. Lincoln, President Trump’s continued circumvention of Congress and the law while he erects monuments to himself, and his announcement that he will sell early access to his Truth Social posts for $100,000 per month, a likely means of knowing how the president will manipulate the markets, comes the news of the Trump administration’s latest maneuver to further undermine the rule of law and evade accountability.
Right goal, wrong strategy: Why Trump’s ‘Made in America’ plan leaves us vulnerable
A generic drug finished in an American factory but dependent on a single overseas supplier for its active ingredient may be less secure than an imported medicine produced at two independent plants with multiple qualified suppliers. That distinction matters as President Donald Trump moves to bring generic-drug manufacturing back to the United States.
Blanche’s expansion of executive privilege builds a moat around the White House | David Adler
Amid headlines of failing health conditions — inadequate food and water — on the U.S.S. Lincoln, President Trump’s continued circumvention of Congress and the law while he erects monuments to himself, and his announcement that he will sell early access to his Truth Social posts for $100,000 per month, a likely means of knowing how the president will manipulate the markets, comes the news of the Trump administration’s latest maneuver to further undermine the rule of law and evade accountability.
Turning Pediatric Cancer Discoveries Into Medicines Requires Better Connections Original
By David Adler, MD, Ph.D., MBA It may sound like an unlikely way to arrive at a career in oncology, but one of the earliest reasons I became interested in cancer was a child in my neighborhood who was diagnosed with leukemia. I remember thinking that when I grew up, I wanted to help make the world free of childhood cancer. That thought eventually faded as my career developed. I started in academic research, where I enjoyed understanding the biology of disease and making new discoveries.
Israel Has No Shortage of Biomedical Startups, but Where Are the Global Companies?
Israel has exceptional biomedical researchers, outstanding universities and hospitals and a remarkable ability to turn scientific discoveries into startups. But consider a simple question: where are the globally leading Israeli biotech-pharmaceutical companies that have emerged from all this research, talent and investment? Most of us could probably name one: Teva. Teva deserves enormous credit.
Pegasus and the Next Way In
Pegasus and the Next Way In - David Adler
Pegasus and the Next Way In
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. Pegasus does not depend on one door. The surveillance software developed by the Israeli company NSO Group can use different routes to gain access to a smartphone.
Opinion: Current efforts to rehabilitate Nixon threaten America’s constitutional democracy
The ongoing efforts to rehabilitate Richard Nixon by the MAGA right and various commentators, as well as Vice President JD Vance, represents a brazen attempt to whitewash the stain on the American escutcheon inflicted by the Watergate President, for the purpose of “normalizing” his politics, his sweeping acts of usurpation and abuse of power, to furnish President Trump with a historical precedent to absolve him of his Nixonian assault on our constitutional system.
Commentary: How shall America live — the urgency of checks and balances
In our continuing conversation about the defining question of the character of our nation — How shall America live? — we address the defining features of American Constitutionalism, first sketched in the 1760s by colonists who were outraged by English laws and practices that trenched upon their natural rights and rights as Englishman and the sweeping powers of King and Parliament.
Chief Justice Roberts, ‘12 Angry Men’ and the importance of dissent in democracy | David Adler
A brief note in a recent edition of SCOTUS Blog shared word of the Supreme Court Justices’ favorite movies. While the Justices are typically guarded in talking about their private lives and activities, Chief Justice John Roberts was enthusiastic in discussing his favorite films, and we credit him for exalting an American classic, “12 Angry Men,” which trumpets the importance of facts, truth, justice, accountability and the willingness to resist unwarranted conformity.
An overlooked opportunity for Israel and Saudi Arabia
(Aug. 22, 2026 / JNS) The question is not whether Israel and Saudi Arabia will normalize relations, but when. The more important questions are what political formula will make normalization possible, what each country stands to gain and what they can build together to make the relationship durable.
Blanche’s memo builds moat around the White House
Amid headlines of failing health conditions – inadequate food and water – on the U.S.S. Lincoln, President Trump’s continued circumvention of Congress and the law while he erects monuments to himself, and his announcement that he will sell early access to his Truth Social Posts for $100,000 per month, which is a likely means of knowing how the president will manipulate the markets, comes the news of the Trump Administration’s latest maneuver to further undermine the rule of law and evade...
The AL Cy Young favorite now has a curveball, and nobody throws it like him
How many pitches does it take to win a Cy Young Award? Do you need a breaking ball? Do you need an offspeed pitch? Or can you do it with all fastballs, if those fastballs are overpowering enough? He'd drop in a curveball every once in a while, sure, but it was a "show-me" pitch, just to have literally one thing a hitter might see that wasn't dead-red.
How Shall America Live: The Urgency of Checks and Balances
In our continuing conversation about the defining question of the character of our nation — How shall America live? — we address the defining features of American Constitutionalism, first sketched in the 1760s by colonists who were outraged by English laws and practices that trenched upon their natural rights and rights as Englishman and the sweeping powers of King and Parliament.
The Blogs: Operation Precision Aliyah
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. While the following story is fictional, the strategic question is serious. At 2:07 a.m., the Mossad Director was summoned to the Prime Minister’s Office.
Israel’s Brain Drain: Time for a Scan and a Neurological Exam?
Please note that the posts on The Blogs are contributed by third parties. The opinions, facts and any media content in them are presented solely by the authors, and neither The Times of Israel nor its partners assume any responsibility for them. Please contact us in case of abuse. In case of abuse, Report this post. Israel worries a lot about brain drain. A scientist leaves for Boston. An engineer moves to London. Another highly trained Israeli builds a career in Sydney.
Operation Precision Aliyah - David Adler
While the following story is fictional, the strategic question is serious. At 2:07 a.m., the Mossad Director was summoned to the Prime Minister’s Office. He arrived expecting Iran, an arms shipment or a terrorist cell. Instead, the Prime Minister pushed a red folder across the desk. “I have a new operation for you.” The director opened it. A pharmaceutical-development executive in Basel. A deep-tech CEO in Boston. A senior Core AI specialist in Toronto.
Israel’s Brain Drain: Time for a Scan and a Neurological Exam?
Israel worries a lot about brain drain. A scientist leaves for Boston. An engineer moves to London. Another highly trained Israeli builds a career in Sydney. Highly trained Israelis are leaving, and Israel has been diagnosed with a familiar condition: brain drain. But a neurologist would not stop at the diagnosis. Consider an ischemic stroke. When blood flow to part of the brain is blocked, brain cells are deprived of the oxygen and nutrients they need. If blood flow is not restored, those cells die.
Chief Justice Roberts, ‘12 Angry Men’ and the importance of dissent in democracy | David Adler Original
A brief note in a recent edition of SCOTUS Blog shared word of the Supreme Court Justices’ favorite movies. While the Justices are typically guarded in talking about their private lives and activities, Chief Justice John Roberts was enthusiastic in discussing his favorite films, and we credit him for exalting an American classic, “12 Angry Men,” which trumpets the importance of facts, truth, justice, accountability and the willingness to resist unwarranted conformity.
How Matt Olson became a king of scoops at first base
Not in the sense of, like, "platoon splits." In the gymnastics sense -- at least, insofar as a 6-foot-4 first baseman can be considered a gymnast. But that's what catching infield throws is: first base gymnastics. You have to get your body into the right position. You have to have the footwork. You have to be able to stretch in every direction. And Olson is one of the very best receiving first basemen in baseball. We have a whole new set of first base fielding stats on Baseball Savant to prove it.
12 angry men
A brief note in the recent edition of SCOTUS Blog shared word of the Supreme Court justices’ favorite movies. While the justices are typically guarded in talking about their private lives and activities, Chief Justice John Roberts was enthusiastic in discussing his favorite films, and we credit him for exalting an American classic, “12 Angry Men,” which trumpets the importance of facts, truth, justice, accountability and the willingness to resist unwarranted conformity.
Celebrating Adams and Jefferson: Will Their Work Inspire?
As the two venerable titans of our nation’s Heroic Age—the season of the American Revolution, the Declaration of Independence and the framing of the Constitution—neared the end of their long lives, both John Adams and Thomas Jefferson yearned to see on July 4, 1826, the 50th anniversary of our country’s birth. Whether providential or not, their dreams were fulfilled when their last wishes were confirmed by family and friends gathered at bedside that, indeed, they were awake on July 4th.
Celebrating Adams and Jefferson: Will their work inspire the hopes and dreams of mankind? | David Adler
As two venerable titans of our nation’s Heroic Age — the season of the American Revolution, the Declaration of Independence and the framing of the Constitution — neared the end of their long lives, John Adams and Thomas Jefferson yearned to see July 4, 1826, the 50th anniversary of our country’s birth. In a Hollywood ending, their wishes were granted. They awakened to greetings from friends and families gathered at their bedsides, and they died that day.
Celebrating Adams and Jefferson: Will their work inspire the hopes and dreams of mankind? | David Adler
As two venerable titans of our nation’s Heroic Age — the season of the American Revolution, the Declaration of Independence and the framing of the Constitution — neared the end of their long lives, John Adams and Thomas Jefferson yearned to see July 4, 1826, the 50th anniversary of our country’s birth. In a Hollywood ending, their wishes were granted. They awakened to greetings from friends and families gathered at their bedsides, and they died that day.
Celebrating Adams and Jefferson: Will their work inspire the hopes and dreams of mankind? | David Adler
As two venerable titans of our nation’s Heroic Age — the season of the American Revolution, the Declaration of Independence and the framing of the Constitution — neared the end of their long lives, John Adams and Thomas Jefferson yearned to see July 4, 1826, the 50th anniversary of our country’s birth. In a Hollywood ending, their wishes were granted. They awakened to greetings from friends and families gathered at their bedsides, and they died that day.
Celebrating Adams And Jefferson: Will Their Work Inspire?
As the two venerable titans of our nation’s Heroic Age — the season of the American Revolution, the Declaration of Independence and the framing of the Constitution—neared the end of their long lives, both John Adams and Thomas Jefferson yearned to see on July 4, 1826, the 50th anniversary of our country’s birth. Whether providential or not, their dreams were fulfilled when their last wishes were confirmed by family and friends gathered at bedside that, indeed, they were awake on July 4th.
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