Parole chiave Ehlers-Danlos Syndrome (EDS) Fibroblast Myofibroblast α-Smooth Muscle Actin (αSMA), Skin biopsy Abstract Aim of the study To investigate, in vivo and in vitro, the fibroblast-to-myofibroblast transition in patients with hypermobile Ehlers-Danlos Syndrome (EDS). To analyze the dermis of patients with classical form of EDS (cEDS) and with hEDS, to identify qualitative and/or quantitative differences in ECM component and ultrastructural changes in collagen.
