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To the Editor, Hou and colleagues (Hou et al. 2026) examined depressive symptoms, sleep disturbances, and pain as mediating and moderating pathways to frailty in two convenience samples of older adults: nursing home residents in Changsha (n = 172) without cancer and outpatient cancer patients in Hong Kong (n = 227). The authors are commended for testing an integrated symptom-cluster framework and for transparent reporting of instrument-level Cronbach's α values.
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