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Highlights • Applying FUS to the dorsal striatum can positively impact the motivational and cognitive aspects of decision making. • Sonication also resulted in significant changes in resting state functional connectivity between the caudate and multiple cortical regions. • Long-term (2 years) FUS application produced no behavioral impairment or neurological trauma evident on T1-weighted, T2-weighted, or susceptibility-weighted MRI scans.
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