Abstract Click to copy section linkSection link copied! The gastrin-releasing peptide receptor (GRPR) is an attractive target for breast cancer (BC) imaging, but the in vivo performance of GRPR-targeted radioligands, such as RM2 and NeoB, is limited by metabolic instability, which may compromise tumor retention. Here, we designed two dimeric RM2-based radioligands, hdPP-01 and hdPP-02, to investigate whether homodimerization could improve the preclinical profile of GRPR-targeted radiotracers.
