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1 Background Haemolytic disease of the fetus and newborn (HDFN) occurs when there is transplacental passage of maternal immunoglobulin G (IgG) red cell antibodies, which bind to paternally-derived antigens on fetal red blood cells, or alternatively those of a donor gamete (either egg/sperm) following in-vitro fertilisation. The fetal red blood cells coated with IgG alloantibodies become attached to Fc receptors of macrophages mainly in the spleen, and are phagocytosed.
Conflicts of Interest Full disclosure of interests are available on request. References 1, , , et al., “Congenital cytomegalovirus infection burden and epidemiologic risk factors in countries with universal screening: A systematic review and meta-analysis,” JAMA Netw Open. 4 (2021): e2120736. 2 and , “Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection,” Rev Med Virol. 17 (2007): 253–276.
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