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Articles by Aaron Schultz
Translating SUVR bias correction to amyloid PET enables early imaging and more accurate simplified quantification
K.A.J. has served as paid consultant for Janssen, Merck, Prothena, and Novartis. He has served as a site coinvestigator for Lilly, Eisai, Janssen, Cerveau, and Biogen. All other authors have no disclosures. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Chronic thermal stress affects growth, liver morphology and molecular responses but allows recovery at optimal temperature in juvenile zebrafish ( Danio rerio )
1 INTRODUCTION Aquatic environments are undergoing unprecedented changes, including rising temperatures, which are continually altering the susceptibility of organisms in both wild and aquaculture settings (Afonso, 2020). Optimal water temperatures are essential for supporting maximal growth, efficient immune responses and maintaining the structural integrity of proteins involved in key biochemical and signal transduction pathways (Roychowdhury et al., 2024).
Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults
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Abstract Plasma phosphorylated tau 217 (pTau217) is an excellent biomarker of Alzheimer’s disease (AD) pathology, but it remains uncertain whether pTau217 can predict amyloid-β (Aβ) and tau accumulation prior to Aβ positron emission tomography (PET) positivity.
By Hyun-Sik Yang, Wai-Ying Wendy Yau, Brian Healy, Michael J. Properzi, Jean-Pierre Bellier, Aaron Schultz, Michelle Farrell, Heidi Jacobs, Rachel Buckley, Kathryn V. Papp, Gad A. Marshall, Rebecca Amariglio, Dorene M. Rentz, Lei Liu, Dennis J. Selkoe, Philip Verghese, Joel B. Braunstein, Keith Johnson, Reisa Sperling, Jasmeer P Chhatwal, Juliana A. U. Anzai, Andrea M. Román Viera, Courtney Maa, Dylan Kirn
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Nature
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Nobody Reads My Newsletter. I Write It Anyway.
What writing into silence every week taught me about leading a school Press enter or click to view image in full size Photo by Allen Y on Unsplash At the end of my first year as principal, a teacher told me the newsletter’s appreciations felt perfunctory. I disagreed. But disagreeing with feedback and dismissing it are different things. So I started paying closer attention to what I was writing.
T-cell lymphoma-associated STAT3 variants impose a type 1 regulatory-like phenotype
Abstract STAT3 signaling is fundamental to T cells, where it underlies basic cellular processes like metabolism and apoptosis, as well as specialized processes like effector differentiation and cytokine production. However, mutations of STAT3 are strikingly prevalent in T-cell cancers, and aberrant or excessive STAT3 signaling is thought to mobilize cellular pathways that encourage malignancy.
Fighting Fire with Fire
Last week, I saw Paul Thomas Anderson’s One Battle After Another. While the film deserves its own article, I want to focus on one aspect of the film’s themes, and that is the use of violence in the service of political ideology. (Spoiler Alert: I talk about some details of the film that go beyond what trailers have shown.) What is striking about the film is that it follows two very different types of people from distinct political ideologies.
Impaired cellular copper regulation in the presence of ApoE4
Aβ β-Amyloid AD late-onset Alzheimer's disease ApoE apolipoprotein E ATP7A/Atp7a copper-transporting ATPase 1 ATP7B copper-transporting ATPase 2 BBB blood–brain barrier BSA bovine serum albumin CCS copper chaperone for superoxide dismutase CHX cycloheximide CNS central nervous system CSF cerebrospinal fluid CuCl2 copper chloride CTR1 copper transporter 1 DMEM/F12 Dulbecco's modified Eagle medium/nutrient mixture F-12 EDTA ethylenediaminetetraacetic acid F-actin filamentous actin FACS...
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)
Background Genetic variants that cause autosomal dominant Alzheimer's disease are highly penetrant but vary substantially regarding age at symptom onset (AAO), rates of cognitive decline, and biomarker changes. Most pathogenic variants that cause autosomal dominant Alzheimer's disease are in presenilin 1 (PSEN1), which encodes the catalytic core of γ-secretase, an enzyme complex that is crucial in production of amyloid β.
Hatchery-Imposed Selection Does Not Impact the Genetic Diversity of Australian Farmed Blue Mussels (Mytilus spp.)
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3D printed porous membrane integrated devices to study the chemoattractant induced behavioural response of aquatic organisms
3D printed porous membrane integrated devices to study the chemoattractant induced behavioural response of aquatic organisms† Biological models with genetic similarities to humans are used for exploratory research to develop behavioral screening tools and understand sensory–motor interactions. Their small, often mm-sized appearance raises challenges in the straightforward quantification of their subtle behavioral responses and calls for new, customisable research tools.
3D Printed Porous Membrane Integrated Devices to Study the Chemoattractant Induced Behavioural Response of Aquatic Organisms
3D Printed Porous Membrane Integrated Devices to Study the Chemoattractant Induced Behavioural Response of Aquatic Organisms Biological models with genetic similarities to humans are used for exploratory research to develop behavioral screening tools and understand sensory-motor interactions. Their small, often mm-sized appearance raises challenges in the straight-forward quantification of their subtle behavioral responses and call for new, customisable research tools.
Association of pathological and volumetric biomarker changes with cognitive decline in clinically normal adults: Harvard Aging Brain Study
Association of pathological and volumetric biomarker changes with cognitive decline in clinically normal adults: Harvard Aging Brain Study Bernard J Hanseeuw, Heidi I Jacobs, Aaron P Schultz, Rachel F Buckley, Michelle E Farrell, Nicolas J Guehl, John A Becker, Michael Properzi, Justin S Sanchez, Yakeel T Quiroz, Patrizia Vannini, Jorge Sepulcre, Hyun-Sik Yang, Jasmeer P Chhatwal, Jennifer Gatchel, Gad A Marshall, Rebecca Amariglio, Kathryn Papp, Dorene M Rentz, Marc Normandin, Julie C Price,...
Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
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Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
REQUIREMENTS You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information. Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease
Abstract Background: The balance between production, clearance, and toxicity of Aβ peptides is central to Alzheimer's disease (AD) pathobiology. Though highly variable in terms of age at symptom onset (AAO), hundreds of variants in PSEN1 cause autosomal dominant forms of AD (ADAD) with nearly complete penetrance.
Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal‐dominant Alzheimer's disease
4 DISCUSSION In this observational study of individuals with ADAD, we investigated whether cross-sectional and longitudinal clinical, cognitive, and biomarker trajectories differed based on the portion of PSEN1 affected by the pathogenic variant.
Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease
Key Points Question Do cortical tau positron emission tomography (PET) patterns vary across clinically unimpaired individuals with abnormal β-amyloid (ie, preclinical Alzheimer disease [AD])? Findings This cross-sectional study found that divergent patterns of cortical tau uptake are present in approximately 10% of individuals with preclinical AD.
Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults
Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults Kathryn V Papp, Rachel F. Buckley, Heidi I.L. Jacobs, Aaron P Schultz, Michael J Properzi, Patrizia Vannini, Bernard J Hanseeuw, Dorene M Rentz, Keith A Johnson, Reisa A Sperling Neurology Mar 2022, 10.1212/WNL.0000000000200137; DOI: 10.1212/WNL.0000000000200137
Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos
Exposure to biogenic phosphorus nano-agromaterials promotes early hatching and causes no acute toxicity in zebrafish embryos With a growing number of studies now exploring the development of novel Phosphorous (P)-based nanomaterials (NMs) for agriculture, there is an increasing concern that these NMs may enter aquatic environments after use and affect aquatic organisms.
Defining the Lowest Threshold for Amyloid-PET to Predict Future Cognitive Decline and Amyloid Accumulation
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Defining the lowest threshold for amyloid-PET to predict future cognitive decline and amyloid accumulation
From the Michelle E. Farrell, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US Shu Jiang, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis Aaron P.
Sex mediates relationships between regional tau pathology and cognitive decline
Research Article Rachel F Buckley PhD https://orcid.org/0000-0002-5356-5537 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA Melbourne School of Psychological Science, University of Melbourne, Victoria, Australia Both authors contributed equally to this work Search for more papers by this author Heidi IL Jacobs PhD...
Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad (Rhinella marina).
Polyacrylic acid coated nanoparticles elicit endothelial cell apoptosis and diminish vascular relaxation in ex vivo perfused iliac arteries of the cane toad (Rhinella marina). Nanoparticles (NP) that penetrate external protective barriers of an animal are most likely transported and distributed to various tissues and organs via the circulatory system.
A new method for biological synthesis of agriculturally relevant nanohydroxyapatite with elucidated effects on soil bacteria
Abstract The study describes a novel and environment friendly route of biosynthesis of nanohydroxyapatite (nHAP). Bacillus licheniformis mediated synthesis of nHAP has been carried out with different phosphate concentrations (2%, 5%, 10% and 20% w/v) of potassium dihydrogen orthophosphate monobasic (K2HPO4).
Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study
Figure 1. Research Design and Serial Tau–Positron Emission Tomography (PET) Surface Images of an Illustrative Participant A, Baseline of this study was defined as the time of baseline FTP imaging (t = 0; where t indicates time in years from baseline). Change in flortaucipir (FTP) was evaluated between t = 0 and t = 2. Pittsburgh compound B (PiB) and cognitive data have been evaluated both between t = −3 and t = 0 and between t = 0 and t = 3.
Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity
Research Articles, Neurobiology of Disease Willem Huijbers, Aaron P. Schultz, Kathryn V. Papp, Molly R. LaPoint, Bernard Hanseeuw, Jasmeer P. Chhatwal, Trey Hedden, Keith A. Johnson and Reisa A. Sperling Journal of Neuroscience 16 January 2019, 39 (3) 548-556; DOI: https://doi.org/10.1523/JNEUROSCI.1397-18.2018 Abstract Animal studies demonstrate that hyperactive neurons facilitate early accumulation and spread of tau and amyloid-β proteins in the pathological cascade of Alzheimer's disease (AD).
Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study | Cardiology | JAMA Neurology | JAMA Network
Key Points Question Is vascular risk associated with prospective cognitive decline in a cohort of clinically normal older adults, additively or synergistically with β-amyloid? Findings In this study, Framingham and other vascular risk algorithms were associated with longitudinal cognitive decline, both alone and synergistically with β-amyloid burden.
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
H.I.L.J. designed the study, analyzed the diffusion and behavioral data, performed statistical analyses and wrote the manuscript. T.H. performed the factor analyses and aided in data interpretation and manuscript preparation. A.P.S. analyzed the PET and structural data and aided in manuscript preparation. J.S. aided in the connectivity data analysis and manuscript preparation. R.D.P. aided in data analysis and manuscript preparation.
Heterogeneity in Suspected Non–Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals
Question Do cognitively normal older individuals with suspected non–Alzheimer disease pathophysiology (SNAP) show evidence of early Alzheimer disease processes? Findings In this longitudinal study, the SNAP group did not show elevated levels of tau or cognitive decline. A small subset of the SNAP group with subthreshold Pittsburgh Compound B values and small hippocampus showed rapid cognitive decline.
Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study
To identify the contribution of cerebrovascular amyloid pathology to cortical atrophy, we evaluated cortical thickness in patients with a monogenic form of CAA largely devoid of parenchymal Alzheimer's disease pathology, as well as in patients with sporadic CAA without dementia.
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