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Abstract Obesity is a significant public health concern that is associated with numerous health risks. Infections are a major complication of obesity, but the mechanisms responsible for increased infection risk are poorly defined. Here, we use a diet induced obesity mouse model and investigate how obesity impacts urinary tract infection (UTI) susceptibility and bladder immune defenses. Our results show that high-fat diet fed female and male mice exhibit increased susceptibility to uropathogenic E.
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests and no conflicts of interest to disclose. Supporting Information Filename Description dom15981-sup-0001-FigureS1.pdfPDF document, 3.9 MB Figure S1. Features of the urinary tract infection (UTI) histopathologic murine kidney scoring system. (A) Kidney sections were cut in transverse section to ensure adequate and repeatable assessment of all components.
Abstract Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes and prolong hospital stays. Consequently, new strategies are needed to prevent and control the spread of antibiotic resistance in uropathogenic bacteria. Over the past two decades, sizeable clinical efforts and research advances have changed urinary tract infection (UTI) treatment and prevention strategies to conserve antibiotic use.
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