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Towards the Development of Sensation-Enabled Skin Substitutes Recent advances in reconstructing the 3D structure of human organs, through 3D biofabrication technologies, have introduced new methods for developing complex organs. Thus, much progress has been made to develop skin substitutes using tissue engineering and regenerative medicine (TERM) technologies.
1 Introduction Large non-healing skin wounds are major health and economic burdens, with over 100 million people worldwide affected by burn injuries alone, annually.[1] The gold-standard therapy for treating extensive burn injuries is split-thickness skin grafts (STSGs), which take skin from a non-injured area of the patient skin and graft into the site of injury.
Abstract : When developing topical semisolid products, it is crucial to consider the metamorphosis of the formulation under the “in use” condition. Numerous critical quality characteristics, including rheological properties, thermodynamic activity, particle size, globule size, and the rate/extent of drug release/permeation, can be altered during this process.
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