Figure 1 Obesity-induced alterations in adipose tissue ECM composition. Summary of obesity-stimulated alterations in adipose tissue ECM composition and level of ECM remodelers compared to lean counterparts. Obesity increased ECM deposition as well as the presence of thicker and more aligned collagen fibers and ECM stiffness (Divoux et al. 2010, Mariman & Wang 2010). The levels of several MMPs and their inhibitors (TIMPs) are regulated in response to obesity (Lin et al. 2016).
