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Key Points Question Are serum programmed cell death 1 ligand 1 (PD-L1) levels and tumor PD-L1 expression associated with aggressive clinicopathologic features of papillary thyroid carcinoma (PTC)? Findings In this cohort study including 62 patients with PTC, serum PD-L1 levels were markedly higher in aggressive vs nonaggressive PTC and were associated with macroscopic extrathyroidal extension and aggressive histology.
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