Research Article Jason Micklefield Corresponding Author E-mail address: jason.micklefield@manchester.ac.uk The University of Manchester, School of Chemistry & Manchester Institute of Biotechnology, 131 Princess Street, M1 7DN Manchester, UNITED KINGDOM Search for more papers by this author Abstract S ‐adenosyl‐l‐methionine (SAM)‐dependent methyltransfer ‐ases (MT) are an important class of enzymes, catalysing methylation of a vast array of small metabolites and biomacromolecules.