Idiopathic nephrotic syndrome (NS) is a prevalent glomerular disease that presents as either steroid sensitive (SSNS) or steroid resistant (SRNS), according to whether complete remission is achieved following corticosteroid treatment. SRNS is by definition only diagnosed after a failed 6-week steroid trial, exposing children to significant adverse effects. Moreover, SRNS confers an increased risk of progression to kidney failure, prompting early personalized treatment.
