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Adam N Trautwig

As seen in: Nature, BioRxiv
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Articles by Adam N Trautwig

Ten protein panel predicts ALS from plasma with high accuracy

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By Woo Jae Kim, Seneshaw Asress, Adam N Trautwig, Eric B. Dammer, Christina N. Fournier, Nicholas T. Seyfried, Zachary T. McEachin, Jonathan Glass, Eleanor Thomas, Mingee Chung
| Nature Verified
Abstract Predictive biomarkers are increasingly used to guide clinical trial design, diagnosis, and management of patients with neurodegenerative diseases. We profiled plasma from 632 ALS patients and 160 healthy controls using the NULISA CNS and Inflammation Panels and applied eXtreme Gradient Boosting (XGBoost) with nested cross-validation and SHapley Additive exPlanations (SHAP) to identify disease-associated proteins.
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Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral Sclerosis

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By Edward Fox, Eric B. Dammer, Adam N Trautwig, Ananth Shantaraman
| BioRxiv
Abstract Background: Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease involving loss of motor neurons, typically results in death within 3-5 years of disease onset. Although roughly 10 % of cases can be linked to a specific inherited mutation (e.g., C9orf72 hexanucleotide repeat expansion or SOD1 mutation), the cause of the majority of cases is unknown. Consequently, there is a critical need for biomarkers that reflect disease onset and progression across ALS subgroups.
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