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Editor’s summary Mammalian cells are packed with millions of ribosomes, tiny machines that decode genetic information into proteins. Although they are essential for this decoding process, they are often viewed as identical particles with little regulatory influence. Zhang et al. developed techniques to observe single ribosomes and examine their composition in different cellular compartments.
Abstract Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types or control cell fate remains unknown. Here, employing quantitative mass spectrometry during human embryonic stem cell differentiation, we identify dozens of ribosome composition changes underlying cell fate specification.
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