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Key Points Question Is soft drink consumption related to depression diagnosis and severity, and is this association mediated by gut microbiome alteration? Findings In this cohort study, soft drink consumption was significantly associated with diagnosis of major depressive disorder, as well as depression severity, across a single-study cohort of 932 clinically diagnosed patients and healthy controls.
The authors have declared no competing interest. This work was funded in part by the consortia grants from the German Research Foundation (DFG) SFB/TRR 393 (project grant no 521379614), the European Unions Horizon 2020 Research and Innovation Program under grant agreement No. 847879 and the Hessian Ministry of Science and Arts (HMWK) LOEWE program (LOEWE Centre DYNAMIC). This work is part of the German multicenter consortium Neurobiology of Affective Disorders.
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