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Articles by Adnan Azim
Validation and further insight into the International Severe Asthma Registry (ISAR) eosinophil gradient algorithm in the Wessex AsThma CoHort of difficult asthma (WATCH) using historical blood eosinophil counts and induced sputum
RESEARCH LETTER Clair Barber, Clair Barber orcid.org/0000-0001-5335-5129 School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK National Institute for Health Research (NIHR) Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust, Southampton, UK Search for more papers by this author Adnan Azim, Adnan Azim orcid.org/0000-0001-5960-1159 School of Clinical and Experimental Sciences, Faculty of...
Real‐world Omalizumab and Mepolizumab treated Difficult Asthma Phenotypes and their Clinical Outcomes
ORIGINAL ARTICLE‐ASTHMA AND RHINITIS Heena Mistry David Hide Asthma and Allergy Research Centre, Isle of Wight, UK Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK Search for more papers by this author Anna Freeman Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK NIHR...
Clinical evaluation of type 2 disease status in a real‐world population of difficult to manage asthma using historic electronic healthcare records of blood eosinophil counts
Abstract Background Blood eosinophil measurement is essential for the phenotypic characterization of patients with difficult asthma and in determining eligibility for anti‐IL‐5/IL‐5Rα biological therapies. However, assessing such measures over limited time spans may not reveal the true underlying eosinophilic phenotype, as treatment, including daily oral corticosteroid therapy, suppresses eosinophilic inflammation and asthma is intrinsically variable.
SARS-CoV2 infection in those on Mepolizumab therapy
Keywords covid-19 severe acute respiratory syndrome coronavirus 2 eosinophils eosinopenia mepolizumab Abbreviation: List:SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), COVID-19 (coronavirus disease 2019), IL (interleukin), ICS (inhaled corticosteroid), LABA (long acting beta agonist), LTRA (leukotriene receptor antagonist), FEV1 (forced expiratory volume in 1 second), PEFR (peak expiratory flow rate), CXR (chest x-ray), CRP (c-reactive protein), PCR (polymerase chain reaction),...
Peripheral airways type 2 inflammation, neutrophilia and microbial dysbiosis in severe asthma
Abstract Background IL‐13 is considered an archetypal T2 cytokine central to the clinical disease expression of asthma. The IL‐13 response genes, which are upregulated in central airway bronchial epithelial of asthma patients, can be normalized by high‐dose inhaled steroid therapy in severe asthma. However, this is not the case within the peripheral airways. We have sought to further understand IL‐13 in the peripheral airways in severe asthma through bronchoalveolar analysis.
Exhaled volatile organic compounds in adult asthma: a systematic review
Adnan Azim, Clair Barber, Paddy Dennison, John Riley, Peter Howarth European Respiratory Journal 2019 54: 1900056; DOI: 10.1183/13993003.00056-2019 Abstract The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds (VOCs).
Exhaled volatile organic compounds in adult asthma: a systematic review
Adnan Azim, Clair Barber, Paddy Dennison, John Riley, Peter Howarth European Respiratory Journal 2019; DOI: 10.1183/13993003.00056-2019 Abstract The search for biomarkers that can guide precision medicine in asthma, particularly those that can be translated to the clinic, has seen recent interest in exhaled volatile organic compounds.
Correction: Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala
The following information is missing from the Funding statement: This study was supported by the European Research Council Executive Agency (ERC). Citation: O’Daly OG, Joyce D, Tracy DK, Azim A, Stephan KE, Murray RM, et al. (2019) Correction: Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala. PLoS ONE 14(6): e0218478. https://doi.org/10.1371/journal.pone.0218478 Published: June 12, 2019 Copyright: © 2019 O’Daly et al.
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