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(A) Ten-week-old C57BL/6J mice were fed cuprizone chow for 6 weeks. VC/FKN was infused into the lateral ventricle for 3 days after cuprizone cessation, and mice were returned to normal chow. (B) Representative TEM images of CC sections from VC- and FKN-infused mice. Arrowheads designate well-preserved mitochondria, asterisks abnormal myelin, yellow and blue small and medium diameter axons, respectively, and purple glial fibrillar protein positive regions.
Highlights • Postnatal and adult murine SVZ precursor cells express Cx3cr1 and bind fractalkine • Fractalkine enhances OPC and oligodendrocyte formation from SVZ NPCs • Inhibition of fractalkine signaling reduces SVZ NPC and OPC oligodendrogenesis • Fractalkine signaling regulates oligodendrogenesis in ex vivo cerebellar slices Summary Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone (SVZ) of the brain contribute to oligodendrogenesis throughout life, in...
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