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Ai-Qun Pan

As seen in: MDPI, Royal Society of Chemistry
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Articles by Ai-Qun Pan

Disruption of a potential disulfide bond of Cys65-Cys141 on the structure and stability of globin X from zebrafish

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By Ai-Qun Pan, Xichun Liu, Hui Han, Shu-Qin Gao
| Royal Society of Chemistry Verified
Disruption of a potential disulfide bond of Cys65-Cys141 on the structure and stability of globin X from zebrafish Globin X is a newly discovered member of the globin family, where its structure and function are not fully understood. In this study, we performed protein modelling studies using Alphafold3 and molecular dynamics simulations, which suggested that the protein adopts a typical globin fold, with the formation of a potential disulfide bond of Cys65 and Cys141.
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Application of Engineered Myoglobins for Biosynthesis of Clofazimine by Integration with Chemical Synthesis

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By Shuai Tang, Li-Juan Sun, Ai-Qun Pan, Jun Huang
| Royal Society of Chemistry Verified
Application of Engineered Myoglobins for Biosynthesis of Clofazimine by Integration with Chemical Synthesis Significant efforts have been made in the design of artificial metalloenzymes. Myoglobin (Mb), an O2 carrier, has been engineered to exhibit different functions. Herein, we applied a series of engineered Mb mutants with peroxidase activity for biosynthesis of clofazimine (CFZ), a potential drug with a broad-spectrum antiviral activity, by integration with chemical synthesis.
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O2 Carrier Myoglobin Also Exhibits β-Lactamase Activity That Is Regulated by the Heme Coordination State

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By Shuai Tang, Xiao-Juan Wang, Shu-Qin Gao, Ai-Qun Pan
| MDPI
Due to planned maintenance work on our platforms, there might be short service disruptions on Saturday, December 3rd, between 15:00 and 16:00 (CET). Submit to this Journal Review for this Journal Edit a Special Issue Article Menu /ajax/scifeed/subscribe Altmetric share Share announcement Help format_quote Cite thumb_up ... Endorse textsms ... Comment Need Help? Support Find support for a specific problem in the support section of our website.
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