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Abstract Remodeling of tumor-draining lymph nodes (tdLNs) can precede overt nodal metastasis and has emerged as a determinant of immune checkpoint blockade (ICB) responsiveness.
Abstract Background: An autoimmune disease with notable clinical variability, primary immune thrombocytopenia is typified by immune-mediated platelet underproduction and destruction. Conventional therapies, including glucocorticoids and splenectomy, are limited by adverse effects, high relapse rates, and surgical risks. Recently, with the in-depth study of immune thrombocytopenia, new targeted drugs have emerged rapidly.
AbstractIntroduction: Obstructive sleep apnea syndrome is characterized by repetitive collapse of the upper airway during sleep and the chronic intermittent hypoxia(CIH) is the most important pathophysiological process of this disease.Objective: The upper airway patency is mainly depends on the contractivity of genioglossus. The genioglossus activity is controlled by 5-HT1A receptor in dorsal raphe neucleus.
AbstractIntroduction: Obstructive sleep apnea syndrome is characterized by recurrent upper airway obstruction and CIH during sleep, but it is still unknown that what effect on upperairway could be caused by CIH and how this effect works.Objective: Recent study showed CIH could induce the increase of a1-adrenoceptor immunoactivity in the hypoglossal nucleus of the rats.
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