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Loading metrics Open Access Peer-reviewed Research Article Citation: Li A, Liu C, Liu X, Chen L, Wang D, Zhu C (2026) Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms. PLoS One 21(8): e0354595.
ORIGINAL RESEARCH article Volume 16 - 2025 | https://doi.org/10.3389/fendo.2025.1730801 This article is part of the Research TopicInsights into the Molecular and Cellular Mechanisms of Insulin ResistanceView all 4 articles 1 Introduction Coronary heart disease (CHD) refers to the process of plaque formation within the major arteries supplying the myocardium, leading to reduced blood flow. Plaque calcification and rupture can lead to thrombosis, thereby posing life-threatening risks (1).
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