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The Ikaros family zinc finger 1 (IKZF1) gene encodes the transcription factor IKAROS, which plays a crucial role in regulating lymphopoiesis and the differentiation of normal myeloid cells [1, 2]. Genetic lesions of IKZF1 are well-established markers of poor prognosis in acute lymphoblastic leukemia (ALL) [3, 4]. However, few studies have addressed IKZF1 alterations in myeloid neoplasms.
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