Irrespective of ethnicity or site (FMC versus RUHS), we find that the concern for risks related to research is the leading barrier for patients enrolling in clinical research. However, the fear of discovering a serious illness was significantly greater in our Hispanic population compared to other ethnicities as well as patients seen at RUHS compared to FMC. On the other hand, work responsibilities ranked higher in NHW and patients seen in the university-based clinic.