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To clarify the impact of chromosomal aberrations on the offspring of patients with testicular germ cell tumour (TGCT) by evaluating the outcomes of intracytoplasmic sperm injection (ICSI). Under the ethical review of Yokohama City University, 12 patients with TGCT and 25 with non-TGCT cancer who had cryopreserved sperm for ICSI for fertility preservation between 1 April 2014 and 31 March 2023 were enrolled.
ART assisted reproductive technology GCNIS germ cell neoplasia in situ ICSI intracytoplasmic sperm injection IQR interquartile range IVF in vitro fertilisation PGT-A pre-implantation genetic testing for aneuploidy RIF recurrent implantation failure RPL recurrent pregnancy loss TGCT testicular germ cell umour Introduction With medical advances emphasising the quality of life of cancer survivors, preservation of fertility has become one of the main concerns.
Loading metrics Open Access Peer-reviewed Research Article Citation: Sueyoshi S, Ijuin A, Ueno H, Miyakoshi A, Hamada H, Toda M, et al. (2025) Single sperm karyotyping of testicular sperm in non-obstructive and obstructive azoospermia using next generation sequencing. PLoS One 20(12): e0338222. https://doi.org/10.1371/journal.pone.0338222 Editor: Joël R.
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