AA-S, MA-J, YAM, FA, CV, AAN, AA, and AA-A are responsible for the acquisition of clinical data and the enrollment of patients. HC, SHA, SC, and SH created the computational pipeline and processed the genetic data. HC and SHA performed analysis and interpretation of data. HC and SHA drafted the manuscript. HC prepared the figures. AA-A, SHA, EVA, and RG performed critical revision of the manuscript for important intellectual content. All authors read and approved the final manuscript.