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Abstract To coexist with its resident microorganisms, the host must have a sense to adjust its behaviour in response to them. In the intestine, a sense for nutrients transduced to the brain through neuroepithelial circuits guides appetitive choices1,2,3,4,5. However, a sense that allows the host to respond in real time to stimuli arising from resident gut microorganisms remains to be uncovered.
Introduction The lateral hypothalamic area (LHA) has been regarded as the “feeding center” since its lesion results in hypophagia and subsequent death (Anand and Brobeck, 1951; Teitelbaum and Epstein, 1962).
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