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Articles by Alba Caceres-Rodriguez
Automated pup-level analysis reveals distinct effects of prenatal CBD and THC exposure on maternal retrieval
Abstract This study examined how prenatal CBD and Δ9-tetrahydrocannabinol (THC) exposure affects maternal caregiving in C57BL/6J mice. We developed the Machine-Automated Scoring of the Pup Retrieval Test (MAS-PRT) to overcome limitations of manual behavioral scoring. MAS-PRT integrates Multi-Animal DeepLabCut for dam and pup tracking with Detectron2 for dynamic nest reconstruction.
Gestational CBD Shapes Insular Cortex in Adulthood
1. Introduction The growing trend of cannabis use among expectant and nursing mothers is sparking mounting alarm, posing a substantial threat to the well-being of unborn babies and newborns [1,2,3,4,5,6,7]. The two main psychoactive compounds in cannabis, tetrahydrocannabinol (THC) and cannabidiol (CBD), can permeate the placenta during pregnancy (as extensively discussed in Rokeby et al. [8]) and also concentrate in breast milk during lactation.
Gestational CBD shapes insular cortex in adulthood
Abstract Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, CBD passes through the placenta, affecting fetal development and impacting offspring behavior. We investigated how prenatal CBD exposure affects the insular cortex (IC), a brain region involved in emotional processing and linked to psychiatric disorders.
Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex
Abstract Background: The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences in behavior and cognition. The IC comprises two distinct subregions: the anterior insular cortex (aIC), that processes emotional and social signals, and the posterior insular cortex (pIC), specialized in interoception and perception of pain.
Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition
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