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Articles by Alberto Bosque
IL-15 and N-803 for HIV Cure Approaches
1. Introduction It has been more than 30 years since the development of antiretroviral therapy (ART) for the Human Immunodeficiency Virus (HIV), which has turned the disease from a death sentence into a manageable chronic condition. Current ART regimens consist of two to three drugs from different classes, which has significantly decreased the development of drug resistance compared to single drug administration [1].
PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent
PB Balakrishnan: conceptualization, data curation, formal analysis, investigation, methodology, visualization, writing – review and editing. CS Holmberg: conceptualization, data curation, formal analysis, investigation, methodology, visualization, writing – review and editing. DK Ledezma: investigation, methodology, writing – review and editing. A Bosque: conceptualization, funding acquisition, supervision, validation, writing – original draft, writing – review and editing.
The Intact Noninducible Latent HIV-1 Reservoir Is Established in an In Vitro Primary TCM Cell Model of Latency
Genome Replication and Regulation of Viral Gene Expression Indra Sarabia, Szu-Han Huang, Adam R. Ward, R. Brad Jones, Alberto Bosque Guido Silvestri, Editor DOI: 10.1128/JVI.01297-20 ABSTRACT The establishment of HIV-1 latency has hindered an HIV-1 cure. “Shock and kill” strategies to target this reservoir aim to induce the latent provirus with latency-reversing agents (LRAs).
The Intact Non-Inducible Latent HIV-1 Reservoir is Established In an In Vitro Primary TCM Cell Model of Latency
Genome Replication and Regulation of Viral Gene Expression Indra Sarabia, Szu-Han Huang, Adam R. Ward, R. Brad Jones, Alberto Bosque DOI: 10.1128/JVI.01297-20 Abstract: The establishment of HIV-1 latency has hindered an HIV-1 cure. “Shock and Kill” strategies to target this reservoir aim to induce the latent provirus with latency reversing agents (LRAs).
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