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Introduction Click to copy section linkSection link copied! The emergence of antimicrobial resistance (AMR) poses a significant and growing health threat to the effective treatment of common bacterial infections worldwide. Over the past decades, the development of novel antibacterial agents has received limited attention, mainly due to economic constraints.
Hit optimization by dynamic combinatorial chemistry on Streptococcus pneumoniae energy-coupling factor transporter ECF-PanT† Herein, we present the first application of target-directed dynamic combinatorial chemistry (tdDCC) to the whole complex of the highly dynamic transmembrane, energy-coupling factor (ECF) transporter ECF-PanT in Streptococcus pneumoniae.
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