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Abstract Copy number variants (CNVs) are strongly implicated in neurological and psychiatric disorders and brain cancer, yet the process by which replication stress generates CNVs—and why some recur while others remain rare—remains poorly understood.
Abstract Cancers are commonly characterised by a complex pathology encompassing genetic, microscopic and macroscopic features, which can be probed individually using imaging and omics technologies. Integrating this data to obtain a full understanding of pathology remains challenging.
On August 4, a massive explosion ripped through the heart of Beirut’s bustling port killing at least 177, injuring about 6,000, causing an estimated 10–15 billion (USD) in property damage, and leaving approximately 300,000 homeless. News reports indicate that the presence of 2750 tons of Ammonium Nitrate (AN) was the reason the initial fire resulted in a devastating blast that sent shockwaves throughout Lebanon’s capital city and the region.
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