Migraine is a profoundly disabling neurologic disorder affecting an estimated 1 billion people globally, including nearly 40 million individuals in the United States.1,2 The socioeconomic burden of the disease is staggering, with associated annual health care costs estimated at $3.2 billion for outpatient visits, $700 million for emergency department utilization, and $375 million for inpatient hospitalizations in the United States alone.3 Although the advent of novel preventive...
