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Despite a number of fundamental studies, the interactions of engineered nanoparticles with the cell plasma membrane are still not well understood. Membrane models, such as lipid monolayers and bilayers, have been used to provide a mechanistic understanding of nanoparticle effects on the structure and integrity of the cell membrane. However, the role of the membrane model itself in regulating nanoparticle–lipid interactions has generally been overlooked.
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