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Articles by Alexander Lander
New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! Compstatins, a class of macrocyclic peptides comprising 13–14 amino acids that bind and inhibit complement component C3, have emerged as a pillar in both experimental and therapeutic modulation of the complement system. (1) As part of innate immunity, complement plays an essential role in host defense and homeostasis via recognition and clearance of foreign and apoptotic cells.
New Analogs of the Compstatin Family of Clinical Complement Inhibitors with Low Picomolar Target Affinity Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! Compstatins, a class of macrocyclic peptides comprising 13–14 amino acids that bind and inhibit complement component C3, have emerged as a pillar in both experimental and therapeutic modulation of the complement system. (1) As part of innate immunity, complement plays an essential role in host defense and homeostasis via recognition and clearance of foreign and apoptotic cells.
Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography - Communications Chemistry
Preparation of bacteriocins and variants The preparation of bacteriocins by native chemical ligation was achieved by splitting the protein sequences into two peptide segments31. The N-terminal fragments (Met1-Ile10 for AucA, Met1-Trp23 for LnqQ) were prepared as a peptide hydrazide53, and the C-terminal fragments (Cys11-Leu51 for AucA, Cys24-Lys53 for LnqQ) carried an Ala→Cys substitution to facilitate the ligation (see Supplementary Information for details of their synthesis).
Use of an asparaginyl endopeptidase for chemo-enzymatic peptide and protein labeling
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Postdischarge Opiate-Prescribing Habits for Primary THA and TKA: A Survey of American Association of Hip and Knee Surgeons Members
Abuse of opiate medications has reached epidemic proportions, and elective total hip arthroplasty (THA) and total knee arthroplasty (TKA) typically require outpatient use of narcotic medications. This survey sought to determine opiate-prescribing habits of members of the American Association of Hip and Knee Surgeons (AAHKS) for patients undergoing primary THA and TKA.
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