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Articles by Ali Danesh
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control - Nature Immunology
Abstract Antiretroviral therapy (ART) interruption typically leads to rapid HIV-1 viral rebound in people with HIV-1. To develop an HIV-1 cure, insight into immunological mechanisms capable of preventing HIV-1 viral rebound is urgently needed. Here, we describe three exceptional post-intervention controllers (PICs) who maintained ART-free virological control for >6.5 years (ongoing), >7.5 years (ongoing) and 2.5 years following administration of broadly neutralizing antibodies.
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones - Nature
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Abstract Clonally expanded CD4+ T-cells harboring rebound-competent HIV persist lifelong during ART1-5. Latency is considered the principal barrier to viral eradication and has resisted pharmacological reversal6,7, yet sustained immune pressure appears to erode reservoirs8-15. Recent advances have yielded glimpses into exceptionally rare reservoir-harboring cells, implicating pro-survival properties in persistence16-18.
By Isabella Ferreira, Alberto Herrera, Tan Huynh, Emily Stone, Noemi Linden, Cristian Ovies, Yanqin Ren, Cíntia Bittar, Ethan Naing, Parul Sinha, Ali Danesh, Eva M Stevenson, Fitty L Liu, Louise Leyre, Elina Wells, Itzayana G. Miller, Marie Canis, Ana Rafaela Teixeira, Susan Moir, Tae-Wook Chun, Colin M. Kovacs, Madeleine S Gastonguay, Shy Genel, Paul Zumbo, Doron Betel, Elias K. Halvas, Guinevere Q. Lee, Rachel Scheck, Marina Caskey, Paul D. Bieniasz, Nathan L. Board, Michel C. Nussenzweig, R. Jones, Virender K. Pal, Shane Vedova, Skylar Shea
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Nature
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The Future of Audiology: Surviving and Thriving
This article is a part of the March/April 2025, Volume 37, Number 2, Audiology Today issue. Barry A. Freeman (BAF): In the early years of audiology, practitioners depended on physician referrals and often relied on physicians to interpret audiological test results and recommend treatment because audiologists were unable to fit and dispense hearing aids. As audiology evolved into an autonomous profession, we gained recognition for our specialized knowledge and skills.
A Brief Commentary on the Consensus Definition of Misophonia
Introduction A small body of academic literature on misophonia has developed over the last decade. This research includes case studies, experimental studies with small convenience samples, and those with more stringent study designs. For a list of studies see Brout et al. (2018).
Journal of the American Academy of Audiology / Abstract
J Am Acad Audiol 2021; 32(09): 562-566 DOI: 10.1055/s-0041-1731733 1 Department of Audiology, Royal Surrey County Hospital, Royal Surrey NHS Foundation Trust, Guildford, United Kingdom , 2 Department of Communication Sciences and Disorders, Florida Atlantic University, Boca Raton, Florida , 3 Department of Experimental Psychology, University of Cambridge, Cambridge Hearing Group, Cambridge, United Kingdom › Author Affiliations Abstract Background and Purpose The aim of this study was to...
Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal
Virus-Cell Interactions Talia M. Mota, Chase D. McCann, Ali Danesh, Szu-Han Huang, Dean B. Magat, Yanqin Ren, Louise Leyre, Tracy D. Bui, Thomas M. Rohwetter, Colin M. Kovacs, Erika Benko, Lynsay MacLaren, Avery Wimpelberg, Christopher M. Cannon, W. David Hardy, Jeffrey T. Safrit, R.
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