Open figure viewer Hepatocyte growth factor (HGF) is a pleiotropic growth factor that signals through the receptor tyrosine kinase c-Met and regulates epithelial growth, morphogenesis, and survival in multiple organs, including the pancreas (1,2). In the endocrine pancreas, c-Met signaling regulates β-cell function. It enhances their resilience to metabolic and inflammatory stress, positioning the HGF/c-Met axis as a key pathway shaping glucose homeostasis in health and diabetes (2–6).
