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Alice Billie Libri

As seen in: Science Magazine
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Articles by Alice Billie Libri

Senataxin promotes recombination fidelity during antigen receptor gene diversification

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By Bo Lu, Alice Billie Libri, STING’s cysteine modificationsBy, John Foley Verified
| Science Magazine Verified
Editor’s summary To ensure a diverse repertoire of antigen receptors in T and B cells, their genes undergo V(D)J recombination, which is initiated by the formation of DNA double-strand breaks (DSBs) by the RAG complex and followed by DNA repair through the nonhomologous end-joining (NHEJ) pathway. Through a CRISPR-Cas9–based screen, Libri et al. identified the RNA/DNA helicase senataxin as playing a previously uncharacterized role in V(D)J recombination.
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STING’s cysteine modifications

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By Bo Lu, Alice Billie Libri, STING’s cysteine modificationsBy, John Foley Verified
| Science Magazine Verified
Abstract Coordinated posttranslational modifications of cysteine residues regulate STING oligomerization and function. SIGN UP FOR THE AWARD-WINNING SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily As part of the innate immune response, cytosolic double-stranded DNA is detected by the sensor cGAS [cyclic guanosine monophosphate (GMP)–adenosine monophosphate (AMP) synthase], which generates the second messenger, cGAMP (cyclic GMP-AMP).
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The E3 ubiquitin ligase ZNRF3 restricts WNT receptor complex activity by stimulating the selective degradation of WNT-engaged FZD

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By Bo Lu, John Foley Verified, Alice Billie Libri, STING’s cysteine modificationsBy
| Science Magazine Verified
Editor’s summary The Wnt signaling pathway is critical for many developmental and homeostatic processes, and it contributes to the growth and progression of various cancers.
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