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Alys N. Aston

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Articles by Alys N. Aston

Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington’s disease mouse model

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By Álvaro Murillo, Melanie Alpaugh, Emma Randall, Meghan Larin, Alysha S Taylor, Alex Mas Monteys, Nina Stöberl, Pascale C. Aeschlimann, Christian Landles, Georgina Osborne, Antoine Mangin, Emmanouil Metzakopian, Nicholas Allen, Jack Puymirat, Gillian Bates, Beverly L. Davidson, Francesca Cicchetti, Mariah Lelos, Vincent Dion, Laura Heraty, Alys N. Aston, Aeverie E. R. Heuchan, Kyle Fears, Soumyasree Bhattacharyya
| Science Magazine Verified
Reference #1 Abstract Supplementary Materials REFERENCES AND NOTES eLetters (0) Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Expanded CAG/CTG repeats cause more than 15 different diseases that all remain without a disease-modifying treatment. Because repeat length accounts for most of the variation in disease severity, contracting CAG/CTG repeats presents an attractive therapeutic avenue.
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