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Grid search was used to determine the optimum thresholds for thickness, roughness, and window length by calculating the overlap between the BVN on ICGA and SIRE (excluding PED) on SD-OCT based on the Dice similarity coefficient (DSC). More details of the DSC are available in Evaluation Metrics. Thickness and roughness thresholds were determined separately and then combined to obtain the SIRE on SD-OCT. Binary morphological operations 41 Soille P.
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