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Articles by Amy C. Mandigo
PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer
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Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer
Molecular Cell Biology Amy C. Mandigo, Ayesha A. Shafi, Jennifer J. McCann, Wei Yuan, Talya S. Laufer, Denisa Bogdan, Lewis Gallagher, Emanuela Dylgjeri, Galina Semenova, Irina A. Vasilevskaya, Matthew J. Schiewer, Chris M. McNair, Johann S. de Bono and Karen E.
Novel oncogenic transcription factor cooperation in RB-deficient cancer
Research Article Amy C Mandigo, Ayesha A Shafi, Jennifer J McCann, Wei Yuan, Talya S Laufer, Denisa Bogdan, Lewis Gallagher, Emanuela Dylgjeri, Galina Semenova, Irina A Vasilevskaya, Matthew J Schiewer, Christopher McNair, Johann S de Bono and Karen E Knudsen DOI: 10.1158/0008-5472.CAN-21-1159 Abstract The retinoblastoma tumor suppressor (RB) is a critical regulator of E2F-dependent transcription, controlling a multitude of pro-tumorigenic networks including but not limited to cell cycle...
RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease
Research Articles Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair and Karen E.
RB/E2F1 as a Master Regulator of Cancer Cell Metabolism in Advanced Disease
Research Article Amy C. Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A. Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J. McCann, Talya S. Laufer, Nicolas Gordon, Irina A. Vasilevskaya, Emanuela Dylgjeri, Saswati N. Chand, Matthew J. Schiewer, Josep Domingo-Domenech, Robert B. Den, Jeff Holst, Peter A. McCue, Johann S. de Bono, Christopher McNair and Karen E.
RB/E2F1 as a master regulator of cancer cell metabolism in advanced disease
Research Article Amy C Mandigo, Wei Yuan, Kexin Xu, Peter Gallagher, Angel Pang, Yi Fang Guan, Ayesha A Shafi, Chellappagounder Thangavel, Beshara Sheehan, Denisa Bogdan, Alec Paschalis, Jennifer J McCann, Talya S Laufer, Nicolas Gordon, Irina A Vasilevskaya, Emanuela Dylgjeri, Saswati N Chand, Matthew J Schiewer, Josep Domingo-Domenech, Robert B Den, Jeff Holst, Peter A. McCue, Johann S.
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair
Abstract Mechanisms regulating DNA repair processes remain incompletely defined. Here, the circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as a tumor specific regulator of DNA repair. Key findings demonstrate that CRY1 expression is androgen-responsive and associates with poor outcome in prostate cancer. Functional studies and first-in-field mapping of the CRY1 cistrome and transcriptome reveal that CRY1 regulates DNA repair and the G2/M transition.
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