Neurofibrillary tangle pathology in the cortex of patients with sporadic AD arises earliest in the rhinal cortices, especially distinct in stellate cells of the layer II entorhinal cortex (ERC) cell clusters (Hyman et al. 1986; Braak and Braak 1991, 1992; Braak and Del Trecidi 2015; Braak and Del Tredici 2015; Kaufman et al. 2018). Tau pathology can be seen initiating in these neurons even in young adults, with tangles appearing even in middle age (Braak and Del Tredici 2015; Liu and Li 2019).