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An Bautmans

As seen in: Wiley Online Library, AHA/ASA Journals
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Articles by An Bautmans

Considerations for Cell and Gene Therapy Programs Entering the Clinical Space

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By Geoffrey A. Walford, Carol Cannon, Kelly E. Duncan, An Bautmans
| Wiley Online Library Verified
Review This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1002/cpt.2971. Abstract Cell and Gene Therapy (CGT) describes a broad category of medicinal products with potential applications to prevent and treat human disease in multiple therapeutic areas.
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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

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By Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans
| AHA/ASA Journals
What Is New? The work reported here demonstrates the de novo invention of a novel macrocyclic peptide, MK-0616, capable of achieving the potency and selectivity of an antibody in a form that can be taken orally. This provides validation and guidance for the use of mRNA display technology, a major advancement in the medicinal chemistry underlying drug discovery. What Are the Clinical Implications?
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