We welcome you to the fourth annual Industry, Innovation, and Entrepreneurship Issue (lovingly referred to here as the "I2E" issue). Here, we look at the roadmap of industry in Erie, the innovations guiding us into the future, and the entrepreneurial backbone that drives our local economy. Some in Erie with their eyes on that future often say that the region finds itself at a crossroads. Pejoratively speaking, being at a crossroads typically isn't seen as a good thing.