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Anca Segall

As seen in: Nature
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Articles by Anca Segall

A human gut-associated picobirnavirus establishes the Picobirnaviridae as the third clade of RNA bacteriophages

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By Tianyu Gan, Anne L. Rosen, Leran Wang, Susan Vernon, Lindsay Droit, Amanda Pinski, Guang Meng Wu, Luis Cardenas Verified, Luis Cárdenas, Kathie Mihindukulasuriya, Megan T. Baldridge, Joanna E. Rimmer, Miles Parkes, Elizabeth A. Dinsdale, Robert Edwards, Anca Segall, Scott A. Handley, Andrew L. Kau, David Wang, Anne Paredes, Zaireen Pios
| Nature Verified
Abstract Picobirnaviruses (PBVs) are commonly detected RNA viruses in human and animal guts and are associated with multiple human diseases. Although PBVs have been assumed to infect vertebrate hosts, there is neither direct evidence for this nor any culture system to propagate PBVs. Here we demonstrate that a PBV infects bacteria and is therefore an RNA phage.
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Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids

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By Ingrid Perez, Omer Nadel, Stephen Nayfach, Luis Ruiz Pestana, Anca Segall, Forest L Rohwer, Simon Roux, Simon White, Antoni Luque, Abelardo Aguilar
| Nature Verified
Abstract The HK97-fold is an ancient, conserved protein structure that assembles protein shells, forming the capsids of Duplodnaviria viruses and prokaryotic biochemical compartments called encapsulsins. It has been proposed that encapsulins evolved from HK97-fold viruses. But the higher complexity of viral capsids represents a biophysical paradox in the evolution of HK97-fold protein shells.
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Mechanisms of Antibiotic Resistance Evolution

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By Dan Andersson, Anca Segall, Uppsala universitet
| avhandlingar.se
Nyckelord: NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution; Sammanfattning: The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems.
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Prophage genomics reveals patterns in phage genome organization and replication

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By Barbara Bailey, Katelyn McNair, Daniel Cuevas, Anca Segall
| BioRxiv
Prophage genomics reveals patterns in phage genome organization and replication Han Suh Kang, Katelyn McNair, Daniel Cuevas, Barbara Bailey, Anca Segall, Robert A Edwards bioRxiv 114819; doi: https://doi.org/10.1101/114819
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