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Articles by Anca Zanfirescu
Evaluating the Efficacy of Secondary Metabolites in Antibiotic-Induced Dysbiosis: A Narrative Review of Preclinical Studies
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Modulating Autophagy in Osteoarthritis: Exploring Emerging Therapeutic Drug Targets
1. Introduction Osteoarthritis (OA) is the most common degenerative joint disease, affecting millions of people worldwide. It is primarily associated with aging, obesity, and joint injuries, and commonly affects the knees, hips, hands, and spine. As the cartilage in joints wears down, patients experience pain, stiffness, and swelling, which significantly reduce their mobility and overall quality of life [1].
Cannabidiol Supplements in Romania: Bridging the Gap Between Marketed Claims and Clinical Reality
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
An Experimental Dynamic Investigation of the Influence of Melatonin, Serotonin and Tryptophan on the Stability of the DNA Structure
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
In Vitro and In Vivo Antihyperglycemic Effects of New Metabiotics from Boletus edulis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Exploring the Multifaceted Potential of Sildenafil in Medicine
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Recent Progress in Gels for Neuropathic Pain
Abstract : Neuropathic pain is a complex and debilitating condition that affects millions of people worldwide. While several treatment options are available, they often have limited efficacy and are associated with adverse effects. In recent years, gels have emerged as a promising option for the treatment of neuropathic pain.
Paclitaxel—A Valuable Tool for Inducing Visceral Pain in Preclinical Testing?
Open AccessArticle by Corina Andrei , Anca Zanfirescu *, Dragoș Paul Mihai and Simona Negreș Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, 020956 Bucharest, Romania * Author to whom correspondence should be addressed. Int. J. Transl. Med.
Natural Active Ingredients and TRPV1 Modulation: Focus on Key Chemical Moieties Involved in Ligand–Target Interaction
Abstract : Diseases such as cancer, neurological pathologies and chronic pain represent currently unmet needs. The existing pharmacotherapeutic options available for treating these conditions are limited by lack of efficiency and/or side effects. Transient receptor potential vanilloid 1 ion channel emerged as an attractive therapeutic target for developing new analgesic, anti-cancer and antiepileptic agents. Furthermore, various natural ingredients were shown to have affinity for this receptor.
Discovery of New Microbial Collagenase Inhibitors
3.1. Collagenase Activity Assay A total of 77 compounds were chosen for the screening on ColA activity based on their molecular diversity and on a set of rules derived from our previous research [29] based on 2D molecular descriptors and Bemis–Murcko scaffolds. The first group of compounds contained natural compounds, while the second one contains synthetic derivatives of several amino acids.
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