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Articles by Anders Thorsted
Population Pharmacokinetics and Pharmacodynamics of Depemokimab in People with Asthma and Chronic Rhinosinusitis with Nasal Polyps
Introduction Interleukin-5 (IL-5) is a core cytokine in type 2 inflammation and has broad multidirectional effects (direct and indirect) on eosinophils, epithelial cells, mast cells, plasma cells, basophils, ILC2s, regulatory T cells, smooth muscle cells, neutrophils, and fibroblasts.1 As such, IL-5 plays a key role in the pathogenesis of airway diseases driven by underlying type 2 inflammation, such as severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).1, 2 Blood eosinophil...
Predicting the Long‐Term Effects of Therapeutic Neutralization of Oncostatin M on Human Hematopoiesis
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Soluble Oncostatin M (OSM), a potential therapeutic target in inflammatory disease, is known to modulate both thrombo- and erythropoiesis. An investigational anti-OSM antibody exhibited reversible thrombocytopenia and anemia in early clinical trials with a short duration of dosing. WHAT QUESTION DID THIS STUDY ADDRESS?
Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
Supporting Information Filename Description psb413046-sup-0001-Supinfo01.csvCSV document, 27.5 KB Supplementary file psb413046-sup-0002-Supinfo02.docxWord 2007 document , 24.2 KB Supplementary file
Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment
Clinical Therapeutics Vibeke Klastrup, Anders Thorsted, Merete Storgaard, Steffen Christensen, Lena E. Friberg, Kristina Öbrink-Hansen DOI: 10.1128/AAC.02556-19 ABSTRACT Pharmacokinetic changes are often seen in patients with severe infections. Administration by continuous infusion has been suggested to optimize antibiotic exposure and pharmacokinetic/pharmacodynamic (PK/PD) target attainment for β-lactams.
Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime
Pharmacology Anders Thorsted, Eva Tano, Kia Kaivonen, Jan Sjölin, Lena E. Friberg, Elisabet I. Nielsen DOI: 10.1128/AAC.02070-19 ABSTRACT The release of inflammatory bacterial products, such as lipopolysaccharide (LPS)/endotoxin, may be increased upon the administration of antibiotics. An improved quantitative understanding of endotoxin release and its relation to antibiotic exposure and bacterial growth/killing may be gained by an integrated analysis of these processes.
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