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Articles by André Aleman
OFC-induced network modularity improves positive symptoms and attentional alertness in schizophrenia: a combined rTMS-fMRI study
Abstract Repetitive Transcranial Magnetic Stimulation (rTMS) targeting the orbitofrontal cortex (OFC) has emerged as a promisingerapeutic option for drug-naïve people with schizophrenia (SCZ). However, the putative underlying mechanisms of OFC-induced physiological effects remain unknown.
Inhibitory control deficits and ventral attention network alterations linked to apathy in schizophrenia
Abstract Individuals with schizophrenia demonstrated impaired inhibitory control and apathy symptoms, which are characterized by a reduction in self-initiated voluntary activities. However, whether deficits in inhibitory control are linked to apathy remains unclear. Here we investigated inhibitory control-related neural networks and associations with interview-based apathy and actigraphy-derived motor activity, an objective measure of apathy.
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study
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By Matthias Kirschner, Benazir Hodzic-Santor, Leda Kennedy, Justine Y. Hansen, Mathilde Antoniades, Igor Nenadic, Tilo Kircher, Axel Krug, Udo Dannlowski, Dominik Grotegerd, Kira Flinkenflügel, Susanne Meinert, Tiana Borgers, Janik Goltermann, Tim Hahn Verified, Joscha Böhnlein, Elisabeth Leehr, Carlotta Barkhau, Aurina Arnatkeviciute, Mark A. Bellgrove, Jeggan Tiego, Pamela DeRosse, Melissa Green, Yann Quidé, Christos Pantelis, Raymond Chan, Yi Wang, Ulrich Ettinger, Martin Debbané, Mélodie Derome, Christian Gaser, Bianca Besteher, Kelly M. Diederen, Tom Spencer, Josselin Houenou, Edith Pomarol-Clotet, Raymond Salvador, Wulf Rössler, Lukasz Smigielski, Veena Kumari, Preethi Premkumar, Kristina Wiebels, James Gilleen, Paul Allen, Jan-Bernard C. Marsman, Irina V. Lebedeva, Anne-Kathrin J. Fett, Iris Sommer, Sanne Koops, Phillip S. Grant, Asia Ferrari, Indrit Bègue, Dennis Hernaus, Maria Jalbrzikowski, Casey Paquola, Sara Larivière, Boris C. Bernhardt, Sofie L. Valk, Bratislav Misic, Theo van Erp, Jessica Turner, Paul Thompson, André Aleman, Alain Dagher, Stefan Kaiser Verified, Gemma Modinos, Tina Meller, Imke Jansen, Alexander Tomyshev
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Nature
Verified
Transcranial electrical stimulation for the treatment of obsessive–compulsive disorder: a triple meta-analysis
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Abstract Obsessive–compulsive disorder (OCD) is a condition with substantial disability and subclinical obsessive–compulsive behaviors affect up to 1 billion people globally. Transcranial electrical stimulation (tES) is emerging as a potential treatment for OCD, yet its effectiveness is uncertain due to the limited number of randomized controlled trials conducted so far.
By Mohammad Ali Salehinejad, Amir-Homayun Hallajian, Miles Wischnewski, André Aleman, Marom Bikson, Daniel M. Blumberger, Jerome Brunelin, Andre R. Brunoni, Zafiris J. Daskalakis, Stevan Nikolin, Frank Padberg, Alexander T. Sack, Odile A. van den Heuvel, Zahra Vaziri, Carmelo M. Vicario, Trevor Robbins, Michael A. Nitsche, Michael Siniatchkin
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Nature
Verified
De ziel van het brein
In 'De ziel van het brein' onderzoekt hersenwetenschapper André Aleman, auteur van o.a. de bestseller 'Het seniorenbrein', de verbinding tussen geloof en neurowetenschap. Waarom geloven zoveel mensen in iets hogers? Is spiritualiteit ingebakken in onze hersenen of is het een product van cultuur en ervaring?
Multi-Site Benchmark Classification of Major Depressive Disorder Using Machine Learning on Cortical and Subcortical Measures
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting.
Waarom mislukken goede voornemens?
Ik heb regelmatig goede voornemens, maar niet in het bijzonder op 1 januari. De magie van die datum als start om te gaan werken aan een goed doel geldt niet voor mij. Daarmee behoor ik tot een minderheid: maar liefst 78 procent van de Nederlanders heeft goede voornemens op 1 januari.
Wie is hier nou verward?
In Wie is hier nou verward? ontzenuwt André Aleman allerlei grote en minder grote opvattingen over ons brein en ons gedrag. Want is het bijvoorbeeld echt zo dat een kind een taal veel makkelijker leert dan een volwassene? En is de angst van veel ouders terecht dat gamen slecht is voor een kinderbrein en het gebruik van suiker zo mogelijk nóg slechter? En wat valt er allemaal te zeggen over mensen met een psychose?
ENIGMA‐Sleep: Challenges, opportunities, and the road map
SCHIELREVIEW ARTICLE Masoud Tahmasian Corresponding Author masoudtahmasian@gmail.com orcid.org/0000-0003-3999-3807 Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran Stein Correspondence Masoud Tahmasian, Institute of Medical Science and Technology, Shahid Beheshti University, Daneshjou Boulevard, Velenjak, P.O. Box 1983969411, Tehran, Iran.
Neural correlates of victimization in psychosis: differences in brain response to angry faces
Abstract Individuals with psychosis are at an increased risk of victimization. Processing of facial expressions has been suggested to be associated with victimization in this patient group. Especially processing of angry expressions may be relevant in the context of victimization. Therefore, differences in brain activation and connectivity between victimized and nonvictimized patients during processing of angry faces were investigated.
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis
Dr. de Kovel and Dr. Francks were funded by the Max Planck Society (Germany). In addition, the work presented here was supported by various funding sources: the ENIGMA Major Depressive Disorder Working Group received support from NIH Big Data to Knowledge (BD2K; award U54 EB020403 to Dr. Thompson) and NIH (grant R01 MH116147 to Dr. Thompson). Dr. Schmaal is supported by a National Health and Medical Research Council Medical Research Future Fund Career Development Fellowship (APP1140764).
A qualitative evaluation of the effects of Metacognitive Reflection and Insight Therapy: ‘Living more consciously’
Objectives Extensive research showed that one of the major difficulties that people with schizophrenia spectrum disorders are struggling with involves their ability to reflect on their own and others’ mental activities, also defined as metacognition. Several new psychotherapies have been developed to assist patients (re)gain metacognitive capacity, including Metacognitive Reflection and Insight Therapy (MERIT).
A qualitative evaluation of the effects of Metacognitive Reflection and Insight Therapy: ‘Living more consciously’
Objectives Extensive research showed that one of the major difficulties that people with schizophrenia spectrum disorders are struggling with involves their ability to reflect on their own and others’ mental activities, also defined as metacognition. Several new psychotherapies have been developed to assist patients (re)gain metacognitive capacity, including Metacognitive Reflection and Insight Therapy (MERIT).
Prefrontal cortex activation during a cognitive reappraisal task is associated with real-life negative affect reactivity
The neural substrate of cognitive reappraisal has been well-mapped. Individuals who successfully downregulate negative affect (NA) by reshaping their thoughts about a potentially emotional situation show augmented activity in the prefrontal cortex (PFC), with attenuated activity in the amygdala. We performed functional neuroimaging with experience sampling to determine whether individual differences in brain activation correspond to differences in real-life NA.
Brain Volumes in Relatives of Patients With Schizophrenia
Context Smaller brain volumes have consistently been found in patients with schizophrenia, particularly in gray matter and medial temporal lobe structures. Although several studies have investigated brain volumes in nonpsychotic relatives of patients with schizophrenia, results have been inconsistent. Objective To determine the magnitude and extent of brain volume differences in first-degree relatives of schizophrenic patients.
Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study
Low levels of insulin-like growth factor-1 (IGF-1), an essential neurotrophic factor, have been associated with worse cognitive function in older adults. However, few studies have assessed the prospective association of serum IGF-1 with cognitive function. We aimed to determine the association between serum IGF-1 on concurrent and prospective cognitive function in a population sample of men aged 40–80 years.
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