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Human control iPSCs were obtained from the Cedars-Sinai iPSC Core cell repository (Los Angeles, USA). Heterozygous fAD PSEN2 (N141I) iPSCs were obtained from both the Cedars-Sinai (Los Angeles, USA) and New York Stem-Cell Foundation cell repositories (New York, USA). All lines were generated from dermal fibroblasts obtained from skin punch biopsies, reprogrammed using either a non-integrating episomal plasmid or mRNA transfection and showed normal karyotyping.
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