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André Krings

As seen in: Color Research & Application, The BMJ
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Articles by André Krings

Risk of a first‐ever acute myocardial infarction and all‐cause mortality with sulphonylurea treatment: A population‐based cohort study

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By Judith van Dalem, André Krings, Olaf H Klungel, Frank de Vries
| Color Research & Application Verified
We investigated the association between the current use of individual sulphonylureas and the risk of a first‐ever acute myocardial infarction (AMI) and all‐cause mortality, in a population‐based cohort study, using primary care data from the Clinical Practice Research Datalink database (2004‐2012). New users (N = 121 869), aged ≥18 years, with at least one prescription for a non‐insulin antidiabetic agent were included. The first prescription defined start of follow‐up.
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Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study | The BMJ

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By Frank de Vries, PhD Candidate, Judith van Dalem, Zuyderland MC, André Krings
| The BMJ Verified
Conclusions  Sulphonylurea treatment in patients with a renal function of less than 30 mL/min/1.73 m 2 should be considered with caution. Moreover, an increased risk of hypoglycaemic events was observed among all users of sulphonylureas. This contrasts with several guidelines that recommend gliclazide as first choice sulphonylurea, and therefore requires further investigation.
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